by J Porada - Related articlesFurthermore several 5-substituted isatin derivatives. differing in the type of their attached “wings” were synthesised and their phase behaviours ... While 5-bromoisatin (1b) was obtained by direct. bromination of isatin,. 4. the other regioisomers, 4-, 6- and 7-bromoisatin (1a, 1c, 1d), were ... We suggest that the mesogens consists of dimers of the 5-substituted isatin derivatives in which. hydrogen bridges are formed between the amine and the 2 ...

by M Gopal - 1977 - Cited by 1 - Related articlesceed for 15 minutes at room temperature (about 28~ 5 ml of potas-. sium iodide solution were added and the liberated iodine titrated ... pared, orange yellow needles m. p., 271 same as that of 5-bromo-. isation-fl-phenyl hydrazone 0. The filtrate was evaporated under reduced pressure and the ... it is suggested that N-bromoacetamide is converted to acetamide. while isatin is brominated to 5-bromo isatin in acidic medium. ...

by BK Wilk - 2005of transformations, i. e. introduction of bromine in the oxindole core followed by alkylation of 5-. bromooxindole (2),396 which was prepared from inexpensive, technical grade 5-bromoisatin (l).' It was found that n-butyllithium could be replaced with potassium tert-butoxide and 1,5- ... A 5-L, four-necked flask was equipped. with mechanical stirrer, condenser with nitrogen adapter, addition funnel, thermometer and. cooling bath. Tetrahydrofuran ...

by RL Thompson - 1953 - Cited by 58 - Related articleszones as well as substituted 5-nitrofuraldehyde. semicarbazones suppress the production of pulmo-. nary lesions in cotton rats inoculated intranasally ... taining 5% normal rabbit serum to give a concen-. tration of 10 -1 . Decimal dilutions extending. through 10 -~ were prepared in the same medium. ... respectively, were 4, 10 and 12. 5-Bromo isatin. thiosemicarbazone was found to be less active. than the unsubstituted compound. The 5-nitro ...

by MD Hall - 2009 - Cited by 6 - Related articlestesting.5 Of the seven isatin-β-thiosemicarbazones predicted in. the DTP compound library to demonstrate MDR1-selective. activity, only 1 and 2 were available for testing while ... 5-nitroisatin substitution in 23 does not enhance activity over. 1). A diverse range of substitutions at both the isatin and phenyl ... 6 was prepared by reacting 5-bromoisatin with. 4-(4′-fluorophenyl)-3-thiosemicarbazide. Yield 97%, orange needles,. mp 238-240 °C dec. 1H ...

by EG Mesropyan - 2001 - Cited by 2 - Related articlesN-Derivatives of isatin and 5-bromo-. isatin were also prepared by Mannich reaction. In extension of our studies in the field of isatin ... N-substituted derivatives of isatin and 5-bromoisatin. We established that reaction of isatin (I) in the. form of its sodium salt with various haloderivatives ... isatin (bromoisatin), 25 mmol of aminoacid, and. 37.5 mmol of paraformaldehyde in 25 ml of glacial. acetic acid was heated on a boiling water bath for 2 h. ...

by J Porada - Related articlesScheme 1: Suzuki Miyaura coupling of bromoisatin derivatives 2a-d with 4- dodecyloxy-phenyl boronic acid (3). While 5-bromoisatin (2b) was obtained by direct ...

by E Katz - 1974 - Cited by 8 - Related articlesThe first group of compounds, which behave similarly to IBT, includes: 5-formylthiazole. thiosemicarbazone, 5-bromoisatin-3-thiosemicarbazone, 4 ... reported: that of 5-formylthiazole thiosemicarbazone and of 5-bromoisatin 3-thiosemicar-. bazone by D. J. Bauer (t963, and personal communication); that ... calf serum and with IBT, picolinaldehyde-5-hydroxy thiosemicarbazone or l-formylisoquinoline thiosemi-. carbazone at a concentration of 28 #M. Virus infectivity ...

Synthesis of Isatin and 5-Bromoisatin Derivatives. E.G.Mesropyan, G.B.Ambartsumyan, A.A.Avetisyan, ...

by J Azizian - 2003 - Cited by 3 - Related articles5-bromoisatin with K2CO3 and convenient alkyl halides in DMF. under microwave irradiation with the high yield, simple work-up. and short time. ... from the isatin and 5-bromoisatin with alkyl halides in the presence. of a convenient base in a short time and with the high yield and simple ... temperature and 5 mL cool water is added. The precipitate thus obtained. Scheme 1. Reaction of isatins (1a–f) with alkyl halides. N-Alkyl Isatins ...